The role of medullary serotonin ( 5 - HT ) neurons in respiratory control : 3 Contributions to eupneic ventilation , CO 2 chemoreception and 4 thermoregulation 5 6 7 Matthew
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7 Matthew R. Hodges and George B. Richerson 8 9 Dept of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226 10 11 Departments of Neurology and Cellular and Molecular Physiology, 12 Yale University, New Haven, CT 06520 13 14 Veteran’s Affairs Medical Center, West Haven, CT 06516 15 16 Address for Correspondence: 17 Matthew R. Hodges 18 BSB-504, Dept of Physiology 19 Medical College of Wisconsin 20 8701 Watertown Plank Road 21 Milwaukee, WI 53226 22 Phone: (414) 456-7528 23 Fax: (414) 456-6546 24 E-mail: [email protected] 25 Articles in PresS. J Appl Physiol (February 4, 2010). doi:10.1152/japplphysiol.01270.2009
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The role of medullary serotonin ( 5 - HT ) neurons in respiratory control : 3 Contributions to eupneic ventilation , CO 2 chemoreception and 4 thermoregulation 5 6 7
7 Matthew R. Hodges and George B. Richerson 8 9 Dept of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226 10 11 Departments of Neurology and Cellular and Molecular Physiology, 12 Yale University, New Haven, CT 06520 13 14 Veteran’s Affairs Medical Center, West Haven, CT 06516 15 16 Address for Correspondence: 17 Matthew R. Hodges 18 BSB-504, Dept of Physiology 19 Medical College of ...
متن کاملHIGHLIGHTED TOPIC Central CO2 Chemoreception in Cardiorespiratory Control The role of medullary serotonin (5-HT) neurons in respiratory control: contributions to eupneic ventilation, CO2 chemoreception, and thermoregulation
Hodges MR, Richerson GB. The role of medullary serotonin (5-HT) neurons in respiratory control: contributions to eupneic ventilation, CO2 chemoreception, and thermoregulation. J Appl Physiol 108: 1425–1432, 2010. First published February 4, 2010; doi:10.1152/japplphysiol.01270.2009.—The functional roles of the medullary raphé, and specifically 5-HT neurons, are not well understood. It has previ...
متن کاملThe role of medullary serotonin (5-HT) neurons in respiratory control: contributions to eupneic ventilation, CO2 chemoreception, and thermoregulation.
The functional roles of the medullary raphé, and specifically 5-HT neurons, are not well understood. It has previously been stated that the role of 5-HT has been so difficult to understand, because "it is implicated in virtually everything, but responsible for nothing"(Cowen PJ. Foreword. In: Serotonin and Sleep: Molecular, Functional and Clinical Aspects, edited by Monti JM, Prandi-Perumal SR,...
متن کاملDefects in breathing and thermoregulation in mice with near-complete absence of central serotonin neurons.
Serotonergic neurons project widely throughout the CNS and modulate many different brain functions. Particularly important, but controversial, are the contributions of serotonin (5-HT) neurons to respiratory and thermoregulatory control. To better define the roles of 5-HT neurons in breathing and thermoregulation, we took advantage of a unique conditional knock-out mouse in which Lmx1b is genet...
متن کاملCentral chemoreception is a complex system function that involves multiple brain stem sites.
CENTRAL CHEMORECEPTION refers to detection of CO2/pH within the brain and the subsequent reflex effects on breathing. It involves multiple sites within the hindbrain (9, 12, 19) as focal acidification in vivo uniquely at these sites stimulates breathing, indicating detection and chemoreflex initiation. This Viewpoint is not all inclusive but focuses on recent reports of substantial decreases in...
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